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PubMed COVID-19 Clinical Care

1811 - 1820 of 60077 results found

mRNA-based therapeutics: looking beyond COVID-19 vaccines

Date
Sunday, March 10, 2024 - 4:00 AM
Description
Recent advances in mRNA technology and its delivery have enabled mRNA-based therapeutics to enter a new era in medicine. The rapid, potent, and transient nature of mRNA-encoded proteins, without the need to enter the nucleus or the risk of genomic

The hidden toll of the pandemic on nonrespiratory patients

Date
Sunday, March 10, 2024 - 4:00 AM
Description
While many empirical studies have focused on the health consequences of COVID-19 for infected individuals, little attention has been given to its consequences for patients with nonrespiratory medical conditions. In this study, we apply machine

Drivers and impact of the early silent invasion of SARS-CoV-2 Alpha

Date
Saturday, March 09, 2024 - 4:00 AM
Description
SARS-CoV-2 variants of concern (VOCs) circulated cryptically before being identified as a threat, delaying interventions. Here we studied the drivers of such silent spread and its epidemic impact to inform future response planning. We focused on

Immunogenicity and safety of a bivalent (omicron BA.5 plus ancestral) SARS-CoV-2 recombinant spike protein vaccine as a heterologous booster dose: interim analysis of a phase 3, non-inferiority, randomised, clinical trial

Date
Saturday, March 09, 2024 - 4:00 AM
Description
BACKGROUND: SARS-CoV-2 variants evade immunity despite vaccination with prototype COVID-19 vaccines or previous infection. The 2019nCoV-311 (part 2) study is evaluating immune responses after two booster doses of a vaccine containing the omicron BA.5